Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway

The activation of cochlear progenitor cells is a promising approach for hair cell (HC) regeneration and hearing recovery. The mechanisms underlying the initiation of proliferation of postnatal cochlear progenitor cells and their transdifferentiation to HCs remain to be determined. We show that Notch...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Li, Wenyan, Wu, Jingfang, Yang, Jianming, Sun, Shan, Chai, Renjie, Chen, Zheng-Yi, Li, Huawei
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291673/
https://ncbi.nlm.nih.gov/pubmed/25535395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1415901112
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