ROCK inhibitor reduces Myc-induced apoptosis and mediates immortalization of human keratinocytes

The Myc/Max/Mad network plays a critical role in cell proliferation, differentiation and apoptosis and c-Myc is overexpressed in many cancers, including HPV-positive cervical cancer cell lines. Despite the tolerance of cervical cancer keratinocytes to high Myc expression, we found that the solitary...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Dakic, Aleksandra, DiVito, Kyle, Fang, Shuang, Suprynowicz, Frank, Gaur, Anirudh, Li, Xin, Palechor-Ceron, Nancy, Simic, Vera, Choudhury, Sujata, Yu, Songtao, Simbulan-Rosenthal, Cynthia M., Rosenthal, Dean, Schlegel, Richard, Liu, Xuefeng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341834/
https://ncbi.nlm.nih.gov/pubmed/27556514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11458
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