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Cooperativity between Verapamil and ATP Bound to the Efflux Transporter P-glycoprotein
The P-glycoprotein (Pgp) transporter plays a central role in drug disposition by effluxing a chemically diverse range of drugs from cells through conformational changes and ATP hydrolysis. A number of drugs are known to activate ATP hydrolysis of Pgp, but coupling between ATP and drug binding is not...
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| Publicado en: | Biochem Pharmacol |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5341695/ https://ncbi.nlm.nih.gov/pubmed/27531061 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2016.08.013 |
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