Structural basis of a novel PD-L1 nanobody for immune checkpoint blockade

The use of antibodies to target immune checkpoints, particularly PD-1/PD-L1, has made a profound impact in the field of cancer immunotherapy. Here, we identified KN035, an anti-PD-L1 nanobody that can strongly induce T-cell responses and inhibit tumor growth. The crystal structures of KN035 complexe...

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Pubblicato in:Cell Discov
Autori principali: Zhang, Fei, Wei, Hudie, Wang, Xiaoxiao, Bai, Yu, Wang, Pilin, Wu, Jiawei, Jiang, Xiaoyong, Wang, Yugang, Cai, Haiyan, Xu, Ting, Zhou, Aiwu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341541/
https://ncbi.nlm.nih.gov/pubmed/28280600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/celldisc.2017.4
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