Ammonium tetrathiomolybdate treatment targets the copper transporter ATP7A and enhances sensitivity of breast cancer to cisplatin

Cisplatin is an effective breast cancer drug but resistance often develops over prolonged chemotherapy. Therefore, we performed a candidate approach RNAi screen in combination with cisplatin treatment to identify molecular pathways conferring survival advantages. The screen identified ATP7A as a the...

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Pubblicato in:Oncotarget
Autori principali: Chisholm, Cristine L., Wang, Haitao, Wong, Ada Hang-Heng, Vazquez-Ortiz, Guelaguetza, Chen, Weiping, Xu, Xiaoling, Deng, Chu-Xia
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341295/
https://ncbi.nlm.nih.gov/pubmed/27806319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12992
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