Platelet secretion of CXCL4 is Rac1‐dependent and regulates neutrophil infiltration and tissue damage in septic lung damage

BACKGROUND AND PURPOSE: Platelets are potent regulators of neutrophil accumulation in septic lung damage. We hypothesized that platelet‐derived CXCL4 might support pulmonary neutrophilia in a murine model of abdominal sepsis. EXPERIMENTAL APPROACH: Polymicrobial sepsis was triggered by coecal ligati...

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Detaylı Bibliyografya
Yayımlandı:Br J Pharmacol
Asıl Yazarlar: Hwaiz, Rundk, Rahman, Milladur, Zhang, Enming, Thorlacius, Henrik
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2015
Konular:
Research Papers
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341222/
https://ncbi.nlm.nih.gov/pubmed/26478565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13325
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