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Streptococcal M1 Protein Triggers Farnesyltransferase-Dependent Formation of CXC Chemokines in Alveolar Macrophages and Neutrophil Infiltration of the Lungs

The M1 serotype of Streptococcus pyogenes plays an important role in streptococcal toxic shock syndrome. Simvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has been shown to inhibit streptococcal M1 protein-induced acute lung damage, although downstream mechanisms re...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Zhang, Songen, Rahman, Milladur, Zhang, Su, Jeppsson, Bengt, Herwald, Heiko, Thorlacius, Henrik
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486054/
https://ncbi.nlm.nih.gov/pubmed/22949548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00696-12
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