Inhibition of the regulator of G protein signalling RGS4 in the spinal cord decreases neuropathic hyperalgesia and restores cannabinoid CB(1) receptor signalling

BACKGROUND AND PURPOSE: Regulators of G protein signalling (RGS) are major determinants of metabotropic receptor activity, reducing the lifespan of the GTP‐bound state of G proteins. Because the reduced potency of analgesic agents in neuropathic pain may reflect alterations in RGS, we assessed the e...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Bosier, Barbara, Doyen, Pierre J., Brolet, Amandine, Muccioli, Giulio G., Ahmed, Eman, Desmet, Nathalie, Hermans, Emmanuel, Deumens, Ronald
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341217/
https://ncbi.nlm.nih.gov/pubmed/26478461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13324
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