The Antimalarial Chloroquine Suppresses LPS-Induced NLRP3 Inflammasome Activation and Confers Protection against Murine Endotoxic Shock

Activation of the NLRP3 inflammasome, which catalyzes maturation of proinflammatory cytokines like IL-1β and IL-18, is implicated and essentially involved in many kinds of inflammatory disorders. Chloroquine (CQ) is a traditional antimalarial drug and also possesses an anti-inflammatory property. In...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Mediators Inflamm
Asıl Yazarlar: Chen, Xiaoli, Wang, Ning, Zhu, Yuanfeng, Lu, Yongling, Liu, Xin, Zheng, Jiang
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Hindawi Publishing Corporation 2017
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5340938/
https://ncbi.nlm.nih.gov/pubmed/28321151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/6543237
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