The nucleoside analog clitocine is a potent and efficacious readthrough agent

Nonsense mutations resulting in a premature stop codon in an open reading frame occur in critical tumor suppressor genes in a large number of the most common forms of cancers and are known to cause or contribute to the progression of disease. Low molecular weight compounds that induce readthrough of...

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Pubblicato in:RNA
Autori principali: Friesen, Westley J., Trotta, Christopher R., Tomizawa, Yuki, Zhuo, Jin, Johnson, Briana, Sierra, Jairo, Roy, Bijoyita, Weetall, Marla, Hedrick, Jean, Sheedy, Josephine, Takasugi, James, Moon, Young-Choon, Babu, Suresh, Baiazitov, Ramil, Leszyk, John D., Davis, Thomas W., Colacino, Joseph M., Peltz, Stuart W., Welch, Ellen M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5340919/
https://ncbi.nlm.nih.gov/pubmed/28096517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.060236.116
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