In vitro metabolism, reaction phenotyping, enzyme kinetics, CYP inhibition and induction potential of ataluren

Por Kong, Ronald, Ma, Jiyuan, Hwang, Seongwoo, Moon, Young‐Choon, Welch, Ellen M., Weetall, Marla, Colacino, Joseph M., Almstead, Neil, Babiak, John, Goodwin, Elizabeth
Publicado no Pharmacol Res Perspect (2020)

Phase 1 Study of Safety, Tolerability, and Pharmacokinetics of PTC299, an Inhibitor of Stress‐Regulated Protein Translation

Por Weetall, Marla, Davis, Thomas, Elfring, Gary, Northcutt, Valerie, Cao, Liangxian, Moon, Young‐Choon, Riebling, Peter, Dali, Mandar, Hirawat, Samit, Babiak, John, Colacino, Joseph, Almstead, Neil, Spiegel, Robert, Peltz, Stuart W.
Publicado no Clin Pharmacol Drug Dev (2016)

Evaluating the mechanism and therapeutic potential of PTC-028, a novel inhibitor of BMI-1 function in ovarian cancer

Por Dey, Anindya, Xiong, Xunhao, Crim, Aleia, Dwivedi, Shailendra Kumar Dhar, Mustafi, Soumyajit Banerjee, Mukherjee, Priyabrata, Cao, Liangxian, Sydorenko, Nadiya, Baiazitov, Ramil, Moon, Young-Choon, Dumble, Melissa, Davis, Thomas, Bhattacharya, Resham
Publicado no Mol Cancer Ther (2017)

TRTH-13. BMI1 IS A THERAPEUTIC TARGET IN RECURRENT MEDULLOBLASTOMA

Por Bakhshinyan, David, Garg, Neha, Manoranjan, Branavan, Venugopal, Chitra, Hallett, Robin, Wang, Xin, Kameda-smith, Michelle, Adile, Ashley, Ramaswamy, Vijay, Davis, Thomas, Weetall, Marla, Moon, Young-choon, Mitra, Siddhartha, Cho, Yoon-Jae, Taylor, Michael, Singh, Sheila
Publicado no Neuro Oncol (2017)

Discovery of Novel Small Molecule Inhibitors of VEGF Expression in Tumor Cells Using a Cell-Based High Throughput Screening Platform

Por Cao, Liangxian, Weetall, Marla, Bombard, Jenelle, Qi, Hongyan, Arasu, Tamil, Lennox, William, Hedrick, Jean, Sheedy, Josephine, Risher, Nicole, Brooks, Peter C., Trifillis, Panayiota, Trotta, Christopher, Moon, Young-Choon, Babiak, John, Almstead, Neil G., Colacino, Joseph M., Davis, Thomas W., Peltz, Stuart W.
Publicado no PLoS One (2016)

The nucleoside analog clitocine is a potent and efficacious readthrough agent

Por Friesen, Westley J., Trotta, Christopher R., Tomizawa, Yuki, Zhuo, Jin, Johnson, Briana, Sierra, Jairo, Roy, Bijoyita, Weetall, Marla, Hedrick, Jean, Sheedy, Josephine, Takasugi, James, Moon, Young-Choon, Babu, Suresh, Baiazitov, Ramil, Leszyk, John D., Davis, Thomas W., Colacino, Joseph M., Peltz, Stuart W., Welch, Ellen M.
Publicado no RNA (2017)

The minor gentamicin complex component, X2, is a potent premature stop codon readthrough molecule with therapeutic potential

Por Friesen, Westley J., Johnson, Briana, Sierra, Jairo, Zhuo, Jin, Vazirani, Priya, Xue, Xiaojiao, Tomizawa, Yuki, Baiazitov, Ramil, Morrill, Christie, Ren, Hongyu, Babu, Suresh, Moon, Young-Choon, Branstrom, Art, Mollin, Anna, Hedrick, Jean, Sheedy, Josephine, Elfring, Gary, Weetall, Marla, Colacino, Joseph M., Welch, Ellen M., Peltz, Stuart W.
Publicado no PLoS One (2018)

BMI-1 targeting interferes with patient-derived tumor-initiating cell survival and tumor growth in prostate cancer

Por Bansal, Nitu, Bartucci, Monica, Yusuff, Shamila, Davis, Stephani, Flaherty, Kathleen, Huselid, Eric, Patrizii, Michele, Jones, Daniel, Cao, Liangxian, Sydorenko, Nadiya, Moon, Young-Choon, Zhong, Hua, Medina, Daniel J., Kerrigan, John, Stein, Mark N., Kim, Isaac Y., Davis, Thomas W., DiPaola, Robert S., Bertino, Joseph R., Sabaawy, Hatem E.
Publicado no Clin Cancer Res (2016)

Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties

Por Cao*, Liangxian, Weetall, Marla, Trotta, Christopher, Cintron, Katherine, Ma, Jiyuan, Kim, Min Jung, Furia, Bansri, Romfo, Charles, Graci, Jason D., Li, Wencheng, Du, Joshua, Sheedy, Josephine, Hedrick, Jean, Risher, Nicole, Yeh, Shirley, Qi, Hongyan, Arasu, Tamil, Hwang, Seongwoo, Lennox, William, Kong, Ronald, Petruska, Janet, Moon, Young-Choon, Babiak, John, Davis, Thomas W., Jacobson, Allan, Almstead, Neil G., Branstrom, Art, Colacino, Joseph M., Peltz, Stuart W.
Publicado no Mol Cancer Ther (2018)