A Powerful Statistical Framework for Generalization Testing in GWAS, with Application to the HCHS/SOL

In GWAS, “generalization” is the replication of genotype-phenotype association in a population with different ancestry than the population in which it was first identified. Current practices for declaring generalizations rely on testing associations while controlling the Family Wise Error Rate (FWER...

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Publicat a:Genet Epidemiol
Autors principals: Sofer, Tamar, Heller, Ruth, Bogomolov, Marina, Avery, Christy L., Graff, Mariaelisa, North, Kari E., Reiner, Alex P., Thornton, Timothy A., Rice, Kenneth, Benjamini, Yoav, Laurie, Cathy C., Kerr, Kathleen F.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5340573/
https://ncbi.nlm.nih.gov/pubmed/28090672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.22029
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