Essential role of DNA methyltransferase 1-mediated transcription of insulin-like Growth Factor 2 in Resistance to Histone Deacetylase Inhibitors

PURPOSE: Histone deacetylase inhibitors (HDIs) are promising anticancer therapies; however, drug resistance limits their efficacy. Here, we investigated the molecular mechanisms underlying HDI resistance, focusing on the mechanism of HDI-mediated induction of insulin-like growth factor 2 (IGF2) base...

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Publicado no:Clin Cancer Res
Main Authors: Min, Hye-Young, Lee, Su-Chan, Woo, Jong Kyu, Jung, Hyun Jin, Park, Kwan Hee, Jeong, Hae Min, Hyun, Seung Yeob, Cho, Jaebeom, Lee, Wooin, Park, Ji Eun, Kwon, So Jung, Lee, Hyo-Jong, Ni, Xiao, Shin, Young Kee, Johnson, Faye M., Duvic, Madeleine, Lee, Ho-Young
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5340567/
https://ncbi.nlm.nih.gov/pubmed/27582487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-0534
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