Improved Therapeutic Effect against Leukemia by a Combination of the Histone Methyltransferase Inhibitor Chaetocin and the Histone Deacetylase Inhibitor Trichostatin A

SUV39H1 is a histone 3 lysine 9 (H3K9)-specific methyltransferase that is important for heterochromatin formation and the regulation of gene expression. Chaetocin specifically inhibits SUV39H1, resulted in H3K9 methylation reduction as well as reactivation of silenced genes in cancer cells. Histone...

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Bibliographische Detailangaben
Hauptverfasser: Tran, Huong Thi Thanh, Kim, Hee Nam, Lee, Il-Kwon, Nguyen-Pham, Thanh-Nhan, Ahn, Jae-Sook, Kim, Yeo-Kyeoung, Lee, Je-Jung, Park, Kyeong-Soo, Kook, Hoon, Kim, Hyeoung-Joon
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Korean Academy of Medical Sciences 2013
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3565135/
https://ncbi.nlm.nih.gov/pubmed/23400519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3346/jkms.2013.28.2.237
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