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DNA Methyltransferase and Histone Deacetylase Inhibitors in the Treatment of Myelodysplastic Syndromes

The recently approved drugs 5-azacitidine and 5-aza-2′-deoxyazacytidine are in wide clinical use for the treatment of myelodysplastic syndrome of all types and chronic myelomonocytic leukemia. These agents were developed based upon an understanding of the importance of epigenetic changes in malignan...

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Autori principali: Griffiths, Elizabeth A., Gore, Steven D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234265/
https://ncbi.nlm.nih.gov/pubmed/18179966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.seminhematol.2007.11.007
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