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The histone deacetylase inhibitor Trichostatin A modulates CD4+ T cell responses

BACKGROUND: Histone deacetylase inhibitors (HDACIs) induce hyperacetylation of core histones modulating chromatin structure and affecting gene expression. These compounds are also able to induce growth arrest, cell differentiation, and apoptotic cell death of tumor cells in vitro as well as in vivo....

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Detalhes bibliográficos
Main Authors: Moreira, José Manuel Afonso, Scheipers, Peter, Sørensen, Poul
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC280656/
https://ncbi.nlm.nih.gov/pubmed/14606959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-3-30
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