Dual oxidase 2 and pancreatic adenocarcinoma: IFN-γ-mediated dual oxidase 2 overexpression results in H(2)O(2)-induced, ERK-associated up-regulation of HIF-1α and VEGF-A

Several NADPH oxidase family members, including dual oxidase 2 [DUOX2], are expressed in human tumors, particularly gastrointestinal cancers associated with long-standing chronic inflammation. We found previously that exposure of pancreatic ductal adenocarcinoma cells to the pro-inflammatory cytokin...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Wu, Yongzhong, Meitzler, Jennifer L., Antony, Smitha, Juhasz, Agnes, Lu, Jiamo, Jiang, Guojian, Liu, Han, Hollingshead, Melinda, Haines, Diana C., Butcher, Donna, Panter, Michaela S., Roy, Krishnendu, Doroshow, James H.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5340089/
https://ncbi.nlm.nih.gov/pubmed/27637085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12032
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