Leukemogenesis Caused by Incapacitated GATA-1 Function

GATA-1 is essential for the development of erythroid and megakaryocytic lineages. We found that GATA-1 gene knockdown female (GATA-1.05/X) mice frequently develop a hematopoietic disorder resembling myelodysplastic syndrome that is characterized by the accumulation of progenitors expressing low leve...

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Autori principali: Shimizu, Ritsuko, Kuroha, Takashi, Ohneda, Osamu, Pan, Xiaoqing, Ohneda, Kinuko, Takahashi, Satoru, Philipsen, Sjaak, Yamamoto, Masayuki
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2004
Soggetti:
Gene Expression
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC533998/
https://ncbi.nlm.nih.gov/pubmed/15572684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.24.10814-10825.2004
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