Loss of Cyclin-dependent Kinase 2 in the Pancreas Links Primary β-Cell Dysfunction to Progressive Depletion of β-Cell Mass and Diabetes

The failure of pancreatic islet β-cells is a major contributor to the etiology of type 2 diabetes. β-Cell dysfunction and declining β-cell mass are two mechanisms that contribute to this failure, although it is unclear whether they are molecularly linked. Here, we show that the cell cycle regulator,...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Kim, So Yoon, Lee, Ji-Hyeon, Merrins, Matthew J., Gavrilova, Oksana, Bisteau, Xavier, Kaldis, Philipp, Satin, Leslie S., Rane, Sushil G.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2017
Materias:
Metabolism
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339765/
https://ncbi.nlm.nih.gov/pubmed/28100774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.754077
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