A Phosphoproteomic Screen Identifies a Guanine Nucleotide Exchange Factor for Rab3A Protein as a Mitogen-activated Protein (MAP) Kinase Phosphatase-5-regulated MAP Kinase Target in Interleukin 6 (IL-6) Secretion and Myogenesis

The mitogen-activated protein kinases (MAPKs) have been shown to regulate skeletal muscle function. Previously, we showed that MAPK phosphatase-5 (MKP-5) negatively regulates myogenesis and regeneration of skeletal muscle through inhibition of p38 MAPK and c-Jun N-terminal kinase (JNK). However, the...

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Vydáno v:J Biol Chem
Hlavní autoři: Lee, Hojin, Min, Kisuk, Yi, Jae-Sung, Shi, Hao, Chang, Woochul, Jackson, Leandra, Bennett, Anton M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2017
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339744/
https://ncbi.nlm.nih.gov/pubmed/28096466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.769208
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