Genetic analysis of Ikaros target genes and tumor suppressor function in BCR-ABL1(+) pre–B ALL

Inactivation of the tumor suppressor gene encoding the transcriptional regulator Ikaros (IKZF1) is a hallmark of BCR-ABL1(+) precursor B cell acute lymphoblastic leukemia (pre–B ALL). However, the mechanisms by which Ikaros functions as a tumor suppressor in pre–B ALL remain poorly understood. Here,...

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Bibliografske podrobnosti
izdano v:J Exp Med
Main Authors: Schjerven, Hilde, Ayongaba, Etapong F., Aghajanirefah, Ali, McLaughlin, Jami, Cheng, Donghui, Geng, Huimin, Boyd, Joseph R., Eggesbø, Linn M., Lindeman, Ida, Heath, Jessica L., Park, Eugene, Witte, Owen N., Smale, Stephen T., Frietze, Seth, Müschen, Markus
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2017
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339667/
https://ncbi.nlm.nih.gov/pubmed/28190001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160049
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