Identification of Residues in the Dengue Virus Type 2 NS2B Cofactor That Are Critical for NS3 Protease Activation

Proteolytic processing of the dengue virus polyprotein is mediated by host cell proteases and the virus-encoded NS2B-NS3 two-component protease. The NS3 protease represents an attractive target for the development of antiviral inhibitors. The three-dimensional structure of the NS3 protease domain ha...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Virol
Auteurs principaux: Niyomrattanakit, Pornwaratt, Winoyanuwattikun, Pakorn, Chanprapaph, Santad, Angsuthanasombat, Chanan, Panyim, Sakol, Katzenmeier, Gerd
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 2004
Sujets:
Replication
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC533897/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15564480/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.78.24.13708-13716.2004
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