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Structure-guided mutagenesis of active site residues in the dengue virus two-component protease NS2B-NS3
BACKGROUND: The dengue virus two-component protease NS2B/NS3 mediates processing of the viral polyprotein precursor and is therefore an important determinant of virus replication. The enzyme is now intensively studied with a view to the structure-based development of antiviral inhibitors. Although 3...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
BioMed Central
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2933675/ https://ncbi.nlm.nih.gov/pubmed/20735839 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1423-0127-17-68 |
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