Structure-guided mutagenesis of active site residues in the dengue virus two-component protease NS2B-NS3

BACKGROUND: The dengue virus two-component protease NS2B/NS3 mediates processing of the viral polyprotein precursor and is therefore an important determinant of virus replication. The enzyme is now intensively studied with a view to the structure-based development of antiviral inhibitors. Although 3...

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Bibliographic Details
Main Authors: Salaemae, Wanisa, Junaid, Muhammad, Angsuthanasombat, Chanan, Katzenmeier, Gerd
Format: Artigo
Language:Inglês
Published: BioMed Central 2010
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2933675/
https://ncbi.nlm.nih.gov/pubmed/20735839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1423-0127-17-68
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