Lipid interactions and angle of approach to the HIV-1 viral membrane of broadly neutralizing antibody 10E8: Insights for vaccine and therapeutic design

Among broadly neutralizing antibodies to HIV, 10E8 exhibits greater neutralizing breadth than most. Consequently, this antibody is the focus of prophylactic/therapeutic development. The 10E8 epitope has been identified as the conserved membrane proximal external region (MPER) of gp41 subunit of the...

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Publicat a:PLoS Pathog
Autors principals: Irimia, Adriana, Serra, Andreia M., Sarkar, Anita, Jacak, Ronald, Kalyuzhniy, Oleksandr, Sok, Devin, Saye-Francisco, Karen L., Schiffner, Torben, Tingle, Ryan, Kubitz, Michael, Adachi, Yumiko, Stanfield, Robyn L., Deller, Marc C., Burton, Dennis R., Schief, William R., Wilson, Ian A.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338832/
https://ncbi.nlm.nih.gov/pubmed/28225819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006212
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