Editing VEGFR2 Blocks VEGF-Induced Activation of Akt and Tube Formation

PURPOSE: Vascular endothelial growth factor receptor 2 (VEGFR2) plays a key role in VEGF-induced angiogenesis. The goal of this project was to test the hypothesis that editing genomic VEGFR2 loci using the technology of clustered regularly interspaced palindromic repeats (CRISPR)-associated DNA endo...

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Bibliografiske detaljer
Udgivet i:Invest Ophthalmol Vis Sci
Main Authors: Huang, Xionggao, Zhou, Guohong, Wu, Wenyi, Ma, Gaoen, D'Amore, Patricia A., Mukai, Shizuo, Lei, Hetian
Format: Artigo
Sprog:Inglês
Udgivet: The Association for Research in Vision and Ophthalmology 2017
Fag:
Biochemistry and Molecular Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338630/
https://ncbi.nlm.nih.gov/pubmed/28241310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.16-20537
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