HIF1α-induced PDGFRβ signaling promotes developmental HSC production via IL-6 activation

Hematopoietic stem cells (HSCs) have the ability to both self-renew and differentiate into all the mature blood cell lineages and thereby reconstitute the entire blood system. As such, HSCs are therapeutically valuable for treatment of hematological malignances and bone marrow failure. We recently s...

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Udgivet i:Exp Hematol
Main Authors: Lim, Sung-Eun, Esain, Virginie, Kwan, Wanda, Theodore, Lindsay N., Cortes, Mauricio, Frost, Isaura M., Liu, Sarah Y., North, Trista E.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338611/
https://ncbi.nlm.nih.gov/pubmed/27751871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2016.10.002
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