Kv1.1 channelopathy abolishes presynaptic spike width modulation by subthreshold somatic depolarization

Although action potentials propagate along axons in an all-or-none manner, subthreshold membrane potential fluctuations at the soma affect neurotransmitter release from synaptic boutons. An important mechanism underlying analog–digital modulation is depolarization-mediated inactivation of presynapti...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Vivekananda, Umesh, Novak, Pavel, Bello, Oscar D., Korchev, Yuri E., Krishnakumar, Shyam S., Volynski, Kirill E., Kullmann, Dimitri M.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2017
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338558/
https://ncbi.nlm.nih.gov/pubmed/28193892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1608763114
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