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Structure of a lipid A phosphoethanolamine transferase suggests how conformational changes govern substrate binding
Multidrug-resistant (MDR) gram-negative bacteria have increased the prevalence of fatal sepsis in modern times. Colistin is a cationic antimicrobial peptide (CAMP) antibiotic that permeabilizes the bacterial outer membrane (OM) and has been used to treat these infections. The OM outer leaflet is com...
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出版年: | Proc Natl Acad Sci U S A |
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主要な著者: | , , , , , , , , , , , |
フォーマット: | Artigo |
言語: | Inglês |
出版事項: |
National Academy of Sciences
2017
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主題: | |
オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5338521/ https://ncbi.nlm.nih.gov/pubmed/28193899 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1612927114 |
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