Structure of a lipid A phosphoethanolamine transferase suggests how conformational changes govern substrate binding

Multidrug-resistant (MDR) gram-negative bacteria have increased the prevalence of fatal sepsis in modern times. Colistin is a cationic antimicrobial peptide (CAMP) antibiotic that permeabilizes the bacterial outer membrane (OM) and has been used to treat these infections. The OM outer leaflet is com...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Anandan, Anandhi, Evans, Genevieve L., Condic-Jurkic, Karmen, O’Mara, Megan L., John, Constance M., Phillips, Nancy J., Jarvis, Gary A., Wills, Siobhan S., Stubbs, Keith A., Moraes, Isabel, Kahler, Charlene M., Vrielink, Alice
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338521/
https://ncbi.nlm.nih.gov/pubmed/28193899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1612927114
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