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Trade-offs between enzyme fitness and solubility illuminated by deep mutational scanning
Proteins are marginally stable, and an understanding of the sequence determinants for improved protein solubility is highly desired. For enzymes, it is well known that many mutations that increase protein solubility decrease catalytic activity. These competing effects frustrate efforts to design and...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5338495/ https://ncbi.nlm.nih.gov/pubmed/28196882 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1614437114 |
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