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Contribution of epigenetic mechanisms to variation in cancer risk among tissues

Recently, it was suggested that tissue variation in cancer risk originates from differences in the number of stem-cell divisions underlying each tissue, leading to different mutation loads. We show that this variation is also correlated with the degree of aberrant CpG island DNA methylation in norma...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Klutstein, Michael, Moss, Joshua, Kaplan, Tommy, Cedar, Howard
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338490/
https://ncbi.nlm.nih.gov/pubmed/28193856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1616556114
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