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Persistence-driven durotaxis: Generic, directed motility in rigidity gradients

Cells move differently on substrates with different elasticities. In particular, the persistence time of their motion is higher on stiffer substrates. We show that this behavior will result in a net transport of cells directed up a soft-to-stiff gradient. Using simple random walk models with control...

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Detalles Bibliográficos
Publicado en:Phys Rev Lett
Autores principales: Novikova, Elizaveta A., Raab, Matthew, Discher, Dennis E., Storm, Cornelis
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338469/
https://ncbi.nlm.nih.gov/pubmed/28256894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1103/PhysRevLett.118.078103
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