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Persistence-driven durotaxis: Generic, directed motility in rigidity gradients

Cells move differently on substrates with different elasticities. In particular, the persistence time of their motion is higher on stiffer substrates. We show that this behavior will result in a net transport of cells directed up a soft-to-stiff gradient. Using simple random walk models with control...

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Bibliografiske detaljer
Udgivet i:Phys Rev Lett
Main Authors: Novikova, Elizaveta A., Raab, Matthew, Discher, Dennis E., Storm, Cornelis
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338469/
https://ncbi.nlm.nih.gov/pubmed/28256894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1103/PhysRevLett.118.078103
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