A temporal proteome dynamics study reveals the molecular basis of induced phenotypic resistance in Mycobacterium smegmatis at sub-lethal rifampicin concentrations

In the last 40 years only one new antitubercular drug has been approved, whilst resistance to current drugs, including rifampicin, is spreading. Here, we used the model organism Mycobacterium smegmatis to study mechanisms of phenotypic mycobacterial resistance, employing quantitative mass spectromet...

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Gepubliceerd in:Sci Rep
Hoofdauteurs: Giddey, Alexander D., de Kock, Elise, Nakedi, Kehilwe C., Garnett, Shaun, Nel, Andrew J. M., Soares, Nelson C., Blackburn, Jonathan M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338346/
https://ncbi.nlm.nih.gov/pubmed/28262820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep43858
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