Zyxin regulates endothelial von Willebrand factor secretion by reorganizing actin filaments around exocytic granules

Endothelial exocytosis of Weibel–Palade body (WPB) is one of the first lines of defence against vascular injury. However, the mechanisms that control WPB exocytosis in the final stages (including the docking, priming and fusion of granules) are poorly understood. Here we show that the focal adhesion...

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Pubblicato in:Nat Commun
Autori principali: Han, Xiaofan, Li, Pin, Yang, Zhenghao, Huang, Xiaoshuai, Wei, Guoqin, Sun, Yujie, Kang, Xuya, Hu, Xueting, Deng, Qiuping, Chen, Liangyi, He, Aibin, Huo, Yingqing, Li, Dong, Betzig, Eric, Luo, Jincai
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338022/
https://ncbi.nlm.nih.gov/pubmed/28256511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14639
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