Zyxin regulates endothelial von Willebrand factor secretion by reorganizing actin filaments around exocytic granules

Endothelial exocytosis of Weibel–Palade body (WPB) is one of the first lines of defence against vascular injury. However, the mechanisms that control WPB exocytosis in the final stages (including the docking, priming and fusion of granules) are poorly understood. Here we show that the focal adhesion...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Han, Xiaofan, Li, Pin, Yang, Zhenghao, Huang, Xiaoshuai, Wei, Guoqin, Sun, Yujie, Kang, Xuya, Hu, Xueting, Deng, Qiuping, Chen, Liangyi, He, Aibin, Huo, Yingqing, Li, Dong, Betzig, Eric, Luo, Jincai
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338022/
https://ncbi.nlm.nih.gov/pubmed/28256511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14639
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