RNF146 Inhibits Excessive Autophagy by Modulating the Wnt-β-Catenin Pathway in Glutamate Excitotoxicity Injury

Glutamate induced excitotoxicity is common in diverse neurological disorders. RNF146 as an E3 ubiquitin ligase protects neurons against excitotoxicity via interfering with Poly (ADP-ribose) (PAR) polymer-induced cell death (parthanatos). However, the neuroprotective role of RNF146 has not been fully...

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Vydáno v:Front Cell Neurosci
Hlavní autoři: Yang, Yuefan, Luo, Peng, Xu, Haoxiang, Dai, Shuhui, Rao, Wei, Peng, Cheng, Ma, Wenke, Wang, Jiu, Xu, Hongyu, Zhang, Lei, Zhang, Sai, Fei, Zhou
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2017
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5337692/
https://ncbi.nlm.nih.gov/pubmed/28321181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2017.00059
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