Structural basis of Ca(2+)/pH dual regulation of the endolysosomal TRPML1 channel

Organellar ion channels are essential for cell physiology. Their activities are often regulated by Ca(2+) and H(+), which are concentrated in many organelles. Here we report a novel structural element critical for Ca(2+)/pH dual regulation of TRPML1, a Ca(2+) release channel crucial for endolysosoma...

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Published in:Nat Struct Mol Biol
Main Authors: Li, Minghui, Zhang, Wei K., Benvin, Nicole M., Zhou, Xiaoyuan, Su, Deyuan, Li, Huan, Wang, Shu, Michailidis, Ioannis E., Tong, Liang, Li, Xueming, Yang, Jian
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5336481/
https://ncbi.nlm.nih.gov/pubmed/28112729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3362
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