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Cryo-EM Structures of the Human Endolysosomal TRPML3 Channel in Three Distinct States
TRPML3 channels are mainly localized to endolysosomes and play a critical role in the endocytic pathway. Their dysfunction causes deafness and pigmentation defects in mice. TRPML3 activity is inhibited by low endolysosomal pH. Here we present cryoelectron microscopy structures of human TRPML3 in the...
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| Publicado no: | Nat Struct Mol Biol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5747366/ https://ncbi.nlm.nih.gov/pubmed/29106414 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3502 |
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