Elevating CXCR7 Improves Angiogenic Function of EPCs via Akt/GSK-3β/Fyn-Mediated Nrf2 Activation in Diabetic Limb Ischemia

RATIONALE: Endothelial progenitor cells (EPCs) respond to SDF-1 through receptors CXCR7 and CXCR4. Whether SDF-1 receptors involves in diabetes induced EPCs dysfunction remains unknown. OBJECTIVE: To determine the role of SDF-1 receptors in diabetic EPCs dysfunction. METHODS AND RESULTS: CXCR7 expre...

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Bibliographic Details
Published in:Circ Res
Main Authors: Dai, Xiaozhen, Yan, Xiaoqing, Zeng, Jun, Chen, Jing, Wang, Yuehui, Chen, Jun, Li, Yan, Barati, Michelle T, Wintergerst, Kupper A., Pan, Kejian, Nystoriak, Matthew A., Conklin, Daniel J., Rokosh, Gregg, Epstein, Paul N., Li, Xiaokun, Tan, Yi
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5336396/
https://ncbi.nlm.nih.gov/pubmed/28137917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.117.310619
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