Exposure to sequestered self-antigens in vivo is not sufficient for the induction of autoimmune diabetes

Although the role of T cells in autoimmunity has been explored for many years, the mechanisms leading to the initial priming of an autoimmune T cell response remain enigmatic. The ‘hit and run’ model suggests that self-antigens released upon cell death can provide the initial signal for a self-susta...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Ono, Nobuyuki, Murakami, Kiichi, Chan, Olivia, Hall, Håkan, Elford, Alisha R., Yen, Patty, Calzascia, Thomas, Spencer, David M., Ohashi, Pamela S., Dhanji, Salim
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5336264/
https://ncbi.nlm.nih.gov/pubmed/28257518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0173176
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