Concurrent inhibition of mTORC1 and mTORC2 by WYE-687 inhibits renal cell carcinoma cell growth in vitro and in vivo

Mammalian target of rapamycin (mTOR)in renal cell carcinoma (RCC) represents a valuable oncotarget for treatment. We here tested the potential anti-RCC activity by a novel mTOR kinase inhibitor WYE-687in vitro and in vivo.WYE-687 was cytotoxic and anti-proliferative to established RCC cell lines (78...

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Vydáno v:PLoS One
Hlavní autoři: Pan, Xiao-dong, Gu, Dong-hua, Mao, Jia-Hui, Zhu, Hua, Chen, Xinfeng, Zheng, Bing, Shan, Yuxi
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2017
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5336203/
https://ncbi.nlm.nih.gov/pubmed/28257457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0172555
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