Absence of IQGAP1 Protein Leads to Insulin Resistance

Insulin binds to the insulin receptor (IR) and induces tyrosine phosphorylation of the receptor and insulin receptor substrate-1 (IRS-1), leading to activation of the PKB/Akt and MAPK/ERK pathways. IQGAP1 is a scaffold protein that interacts with multiple binding partners and integrates diverse sign...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Chawla, Bhavna, Hedman, Andrew C., Sayedyahossein, Samar, Erdemir, Huseyin H., Li, Zhigang, Sacks, David B.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5336162/
https://ncbi.nlm.nih.gov/pubmed/28082684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.752642
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