A Cdc48 “Retrochaperone” Function Is Required for the Solubility of Retrotranslocated, Integral Membrane Endoplasmic Reticulum-associated Degradation (ERAD-M) Substrates

A surprising feature of endoplasmic reticulum (ER)-associated degradation (ERAD) is the movement, or retrotranslocation, of ubiquitinated substrates from the ER lumen or membrane to the cytosol where they are degraded by the 26S proteasome. Multispanning ER membrane proteins, called ERAD-M substrate...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Neal, Sonya, Mak, Raymond, Bennett, Eric J., Hampton, Randolph
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2017
Schlagworte:
Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5336148/
https://ncbi.nlm.nih.gov/pubmed/28077573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.770610
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