Retrotranslocation of a viral A/B toxin from the yeast endoplasmic reticulum is independent of ubiquitination and ERAD

K28 is a viral A/B toxin that traverses eukaryotic cells by endocytosis and retrograde transport through the secretory pathway. Here we show that toxin retrotranslocation from the endoplasmic reticulum (ER) requires Kar2p/BiP, Pdi1p, Scj1p, Jem1p, and proper maintenance of Ca(2+) homeostasis. Neithe...

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Hlavní autoři: Heiligenstein, Susanne, Eisfeld, Katrin, Sendzik, Tanja, Jimenéz-Becker, Natalia, Breinig, Frank, Schmitt, Manfred J
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1618096/
https://ncbi.nlm.nih.gov/pubmed/17006544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601350
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