Prolonged high-fat diet induces gradual and fat depot-specific DNA methylation changes in adult mice

High-fat diets (HFD) are thought to contribute to the development of metabolism-related diseases. The long-term impact of HFD may be mediated by epigenetic mechanisms, and indeed, HFD has been reported to induce DNA methylation changes in white adipose tissue (WAT) near metabolism related genes. How...

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Publicado no:Sci Rep
Main Authors: Zwamborn, Ramona A. J., Slieker, Roderick C., Mulder, Petra C. A., Zoetemelk, Inge, Verschuren, Lars, Suchiman, H. Eka D., Toet, Karin H., Droog, Simone, Slagboom, P. Eline, Kooistra, Teake, Kleemann, Robert, Heijmans, Bastiaan T.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5335669/
https://ncbi.nlm.nih.gov/pubmed/28256596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep43261
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