Copper-catalyzed Direct 2-Arylation of Benzoxazoles and Benzoimidazoles with Aryl Bromides and Cytotoxicity of Products

An efficient copper-catalyzed direct 2-arylation of benzoxazoles and benzoimidazoles with aryl bromides is presented. The CuI/PPh(3)-based catalyst promotes the installation of various aryl and heteroaryl groups through a C-H activation process in good to excellent yields. The cytotoxicity of obtain...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Jia, Nan-Nan, Tian, Xin-Chuan, Qu, Xiao-Xia, Chen, Xing-Xiu, Cao, Ya-Nan, Yao, Yun-Xin, Gao, Feng, Zhou, Xian-Li
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5335610/
https://ncbi.nlm.nih.gov/pubmed/28256577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep43758
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