A Negative Allosteric Modulator for α5 Subunit-Containing GABA Receptors Exerts a Rapid and Persistent Antidepressant-Like Action without the Side Effects of the NMDA Receptor Antagonist Ketamine in Mice

New antidepressant pharmacotherapies that provide rapid relief of depressive symptoms are needed. The NMDA receptor antagonist ketamine exerts rapid antidepressant actions in depressed patients but also side effects that complicate its clinical utility. Ketamine promotes excitatory synaptic strength...

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Foilsithe in:eNeuro
Main Authors: Zanos, Panos, Nelson, Mackenzie E., Highland, Jaclyn N., Krimmel, Samuel R., Georgiou, Polymnia, Gould, Todd D., Thompson, Scott M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Society for Neuroscience 2017
Ábhair:
New Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5334634/
https://ncbi.nlm.nih.gov/pubmed/28275719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0285-16.2017
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