A Negative Allosteric Modulator for α5 Subunit-Containing GABA Receptors Exerts a Rapid and Persistent Antidepressant-Like Action without the Side Effects of the NMDA Receptor Antagonist Ketamine in Mice

New antidepressant pharmacotherapies that provide rapid relief of depressive symptoms are needed. The NMDA receptor antagonist ketamine exerts rapid antidepressant actions in depressed patients but also side effects that complicate its clinical utility. Ketamine promotes excitatory synaptic strength...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:eNeuro
Main Authors: Zanos, Panos, Nelson, Mackenzie E., Highland, Jaclyn N., Krimmel, Samuel R., Georgiou, Polymnia, Gould, Todd D., Thompson, Scott M.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2017
Assuntos:
New Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5334634/
https://ncbi.nlm.nih.gov/pubmed/28275719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0285-16.2017
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados