Aging impairs double‐strand break repair by homologous recombination in Drosophila germ cells

Aging is characterized by genome instability, which contributes to cancer formation and cell lethality leading to organismal decline. The high levels of DNA double‐strand breaks (DSBs) observed in old cells and premature aging syndromes are likely a primary source of genome instability, but the unde...

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Pubblicato in:Aging Cell
Autori principali: Delabaere, Laetitia, Ertl, Henry A., Massey, Dashiell J., Hofley, Carolyn M., Sohail, Faraz, Bienenstock, Elisa J., Sebastian, Hans, Chiolo, Irene, LaRocque, Jeannine R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2016
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5334535/
https://ncbi.nlm.nih.gov/pubmed/28000382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12556
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